Helicobacter-Associated Chronic Inflammation and Gastrointestinal Cancer
نویسندگان
چکیده
منابع مشابه
Chronic gastrointestinal inflammation.
Chronic gastrointestinal inflammation is one of the most common types of inflammatory process which affects humans. It is diverse in aetiology, pathogenesis and manifestation. There are also features of chronic inflammation at different sites within the gastrointestinal tract which provide a common thread in terms of the approaches which may be used in investigating these intriguing processes. ...
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The involvement of macrophages in chronic inflammatory conditions has been the subject of considerable experimental investigation in recent years. Macrophages are able to secrete a wide range of biologically active compounds. They are important in the control of infection and, through their immunological and non-immunological receptors, macrophages interact with other cell types and a wide vari...
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A substantial body of evidence supports the conclusion that chronic inflammation can predispose an individual to cancer, as demonstrated by the association between chronic inflammatory bowel diseases and the increased risk of colon carcinoma. Chronic inflammation is caused by a variety of factors, including bacterial, viral, and parasitic infections, chemical irritants, and nondigestible partic...
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Helicobacter pylori (H. pylori) is a gram-negative microaerophilic bacterium that has been introduced as a cause of mucosal inflammation and gastric cancer. The most important pathogenic factors are VacA and CagA, which are associated with increased disease severity in clinical strains. Autophagy is a protected lysosomal degradation pathway degrading cytoplasmic content and is important in host...
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Helicobacter pylori adherence in the human gastric mucosa involves specific bacterial adhesins and cognate host receptors. Here, we identify sialyl-dimeric-Lewis x glycosphingolipid as a receptor for H. pylori and show that H. pylori infection induced formation of sialyl-Lewis x antigens in gastric epithelium in humans and in a Rhesus monkey. The corresponding sialic acid-binding adhesin (SabA)...
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ژورنال
عنوان ژورنال: AACR Education book
سال: 2008
ISSN: 1943-6475
DOI: 10.1158/aacr.edb-08-8116